Bruno Franzetti is a research director at the CNRS. He heads an interdisciplinary research group at the IBS Institut de biologie structuraleUnité Mixte de Recherche (UMR 5075) created by CEA, CNRS and Université Grenoble Alpes, as well as a national research group (GDR) on Archaeology. His work aims to develop Archean biological systems to dissect complex cellular functions, develop new methods in structural biology and research new biocatalysts and drugs derived from the biodiversity of extremophilic microorganisms. He has been responsible for several research programs aimed at understanding the adaptation of microorganisms to extreme environments. In this context, he discovered and characterized several cellular machineries responsible for the targeted destruction of cellular components.